Johan W M Heemskerk Selected Research

Thrombin

3/2022	Reversing direct factor Xa or thrombin inhibitors: Factor V addition to prothrombin complex concentrate is beneficial in vitro.
12/2021	Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation.
9/2021	Molecular Proteomics and Signalling of Human Platelets in Health and Disease.
7/2018	Integrating platelet and coagulation activation in fibrin clot formation.
1/2018	Platelet heterogeneity in activation-induced glycoprotein shedding: functional effects.
11/2017	Platelet populations and priming in hematological diseases.
11/2016	TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report.
5/2016	Platelets and coagulation in thrombus formation: aberrations in the Scott syndrome.
4/2016	Platelet Control of Fibrin Distribution and Microelasticity in Thrombus Formation Under Flow.
3/2016	Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes.

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Johan W M Heemskerk Research Topics

Disease

108	Thrombosis (Thrombus) 04/2022 - 11/2002
22	Hemorrhage 06/2022 - 03/2003
9	Atherosclerotic Plaque (Atheroma) 01/2022 - 04/2010
9	Scott Syndrome 11/2016 - 04/2003
8	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 09/2004
8	Atherosclerosis 01/2021 - 11/2010
7	Inflammation (Inflammations) 07/2021 - 06/2010
6	Neoplasms (Cancer) 06/2022 - 10/2016
5	Thromboembolism 12/2018 - 03/2003
4	Thrombocytopenia (Thrombopenia) 12/2021 - 02/2007
4	Embolism (Embolus) 10/2020 - 11/2002
4	Vascular System Injuries 07/2013 - 01/2007
3	Renal Cell Carcinoma (Grawitz Tumor) 06/2022 - 10/2016
3	Wounds and Injuries (Trauma) 03/2022 - 01/2008
3	Myocardial Infarction 02/2022 - 07/2010
3	Venous Thrombosis (Deep-Vein Thrombosis) 01/2021 - 05/2008
3	Hyperlipidemias (Hyperlipidemia) 12/2020 - 11/2008
3	Rupture 08/2014 - 01/2012
3	Stroke (Strokes) 07/2010 - 12/2002
2	Thrombophilia 05/2022 - 02/2022
2	Hemophilia A (Haemophilia) 01/2018 - 06/2015
2	Acute Coronary Syndrome 01/2018 - 09/2015
2	Thrombasthenia (Glanzmann Thrombasthenia) 04/2016 - 05/2003

Drug/Important Bio-Agent (IBA)

51	CollagenIBA 02/2022 - 08/2002
33	FibrinIBA 03/2022 - 11/2007
31	Thrombin FDA Link 03/2022 - 12/2002
22	PhosphatidylserinesIBA 02/2022 - 08/2002
16	Glycoproteins (Glycoprotein)IBA 01/2022 - 08/2002
16	Adenosine Diphosphate (ADP)IBA 01/2022 - 11/2002
15	IntegrinsIBA 12/2021 - 02/2004
11	Thromboplastin (Tissue Factor)IBA 12/2021 - 07/2005
11	Proteins (Proteins, Gene)FDA Link 11/2021 - 07/2010
9	Hemostatics (Antihemorrhagics)IBA 06/2022 - 04/2007
9	Apolipoproteins E (ApoE)IBA 04/2022 - 01/2012
7	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2022 - 12/2002
7	von Willebrand FactorIBA 01/2021 - 01/2011
7	Blood Coagulation Factors (Coagulation Factor)IBA 07/2019 - 01/2007
6	AnticoagulantsIBA 01/2020 - 03/2003
5	Tyrosine Kinase InhibitorsIBA 06/2022 - 10/2016
5	Peptides (Polypeptides)IBA 02/2022 - 02/2004
5	Purinergic P2 Receptors (ADP Receptor)IBA 01/2022 - 03/2003
5	Protein Isoforms (Isoforms)IBA 07/2010 - 11/2006
4	Sunitinib (Sutent)FDA Link 06/2022 - 10/2016
4	Thromboxane A2 (A2, Thromboxane)IBA 01/2022 - 04/2003
4	CD40 Ligand (CD40L)IBA 01/2021 - 11/2010
4	platelet membrane glycoprotein VIIBA 01/2021 - 07/2010
4	Phosphotransferases (Kinase)IBA 10/2020 - 08/2002
4	Clopidogrel (Plavix)FDA Link 10/2020 - 06/2005
4	Collagen ReceptorsIBA 06/2019 - 02/2004
4	Protein Kinase CIBA 07/2011 - 03/2007
4	Fish OilsIBA 11/2008 - 03/2003
3	Factor Xa (Coagulation Factor Xa)IBA 03/2022 - 06/2015
3	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2022 - 01/2021
3	Syk KinaseIBA 01/2022 - 06/2019
3	Collagen Type I (Type I Collagen)IBA 01/2022 - 02/2004
3	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2020
3	TicagrelorIBA 01/2022 - 12/2011
3	Pharmaceutical PreparationsIBA 12/2021 - 02/2009
3	ProteomeIBA 09/2021 - 10/2016
3	ChemokinesIBA 07/2021 - 03/2015
3	CholesterolIBA 12/2020 - 12/2014
3	C-Type Lectins (C-Type Lectin)IBA 01/2019 - 07/2014
3	Phospholipids (Phosphatides)FDA LinkGeneric 11/2016 - 03/2013
3	ferric chlorideIBA 02/2015 - 04/2010
3	Factor XII (Hageman Factor)IBA 08/2014 - 07/2009
3	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 05/2013 - 09/2004
2	Adenosine (Adenocard)FDA LinkGeneric 05/2022 - 01/2018
2	Factor V (Coagulation Factor V)IBA 03/2022 - 01/2020
2	CoagulantsIBA 02/2022 - 07/2009
2	Protein CIBA 02/2022 - 01/2020
2	ThrombomodulinIBA 02/2022 - 01/2020
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2022 - 11/2006
2	Dasatinib (BMS 354825)FDA Link 01/2022 - 10/2021
2	2- (2- aminocyclohexylamino)- 4- (m- tolylamino)pyrimidine- 5- carboxamideIBA 01/2022 - 06/2019
2	Factor VIIa (Activated Factor VII)IBA 12/2021 - 08/2014
2	CalciumIBA 10/2021 - 01/2019
2	pazopanib FDA Link 10/2021 - 01/2018
2	LigandsIBA 01/2021 - 06/2014
2	Factor XIIIaIBA 01/2021 - 08/2009
2	Fibrinogen (Factor I)FDA Link 01/2021 - 01/2008
2	factor V LeidenIBA 01/2020 - 05/2008
2	LDL Receptors (LDL Receptor)IBA 10/2019 - 12/2014
2	Collagen Type III (Type III Collagen)IBA 10/2019 - 04/2013
2	Tyrosine (L-Tyrosine)FDA Link 01/2018 - 10/2016
2	Phenobarbital (Luminal)FDA Link 04/2016 - 08/2014
2	CalpainIBA 02/2016 - 05/2013
2	AnoctaminsIBA 02/2016 - 03/2014
2	Ion Channels (Ion Channel)IBA 02/2016 - 05/2003
2	Epinephrine (Adrenaline)FDA LinkGeneric 02/2015 - 05/2003
2	Platelet Glycoprotein GPIb-IX Complex (Glycoprotein Ib)IBA 04/2013 - 01/2011
2	estropipate (Ogen)FDA LinkGeneric 04/2010 - 11/2007
2	Phospholipases (Phospholipase)IBA 07/2009 - 12/2005
2	Triglycerides (Triacylglycerol)IBA 11/2008 - 01/2007
2	Integrin alpha2beta1IBA 11/2007 - 04/2003

Therapy/Procedure

10	Therapeutics 10/2020 - 11/2006
3	Secondary Prevention 01/2022 - 03/2003
2	Lab-On-A-Chip Devices 11/2019 - 01/2012
2	Ligation 12/2018 - 01/2012
2	Drug Therapy (Chemotherapy) 01/2018 - 02/2007
2	Punctures 04/2007 - 11/2002